Clinically Proven Efficacy In Sore Throat Pain
Ibuprofen offered statistically significant effective sore throat relief in the following study:
Clinical Pharmacology and Therapeutics, 1988
- A double-blind, single dose parallel study was conducted to evaluate treatment of sore throat pain. Ibuprofen was more effective on all rating scales from 180 to 360 minutes vs. acetaminophen and at all time points vs. placebo .14*
*Schachtel BP et al conducted a double-blind, single-dose parallel study of patients with tonsillopharyngitis who randomly received either 400 mg ibuprofen, 1000 mg acetaminophen or placebo. At hourly intervals for 6 hours, patients reported pain intensity and pain relief on conventional scales and two sensory qualities of throat pain on two new visual analogy scales.
Expired Advil Cold And Sinus Plus Tablet
- Taking a single dose of expired Advil Cold And Sinus Plus Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
What Form Does This Medication Come In
Each light gold, liquid-filled gelatin capsule contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: D& C Yellow No. 10, FD& C Red No. 40, fractionated coconut oil, gelatin, iron oxide, polyethylene glycol, polyvinyl acetate phthalate, potassium hydroxide, propylene glycol, purified water, sorbitan, and sorbitol.
Each beige, sugar-coated caplet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: acetylated monoglyceride, ammonium hydroxide, carnauba wax, cellulose, cornstarch, croscarmellose sodium, iron oxides, parabens, pharmaceutical glaze, pharmaceutical shellac, povidone, pregelatinized starch, silicon dioxide, sodium benzoate, sodium lauryl sulfate, stearic acid, sucrose, and titanium dioxide.
Each caplet contains 200 mg of ibuprofen and 30 mg of pseudoephedrine. Nonmedicinal ingredients: acetylated monoglycerides, carnauba wax, cellulose, cornstarch, croscarmellose sodium, ethoxyethanol, iron oxides, lecithin, parabens, pharmaceutical glaze, pharmaceutical shellac, povidone, pregelatinized starch, silicon dioxide, simethicone, sodium benzoate, sodium lauryl sulfate, stearic acid, sucrose, and titanium dioxide.
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Hepatic And Renal Safety Profile
Clinical studies suggest that ibuprofen was associated with less acute liver injury compared to other NSAIDs:
Archives of Internal Medicine, 1994
- The lowest incidence of liver injury among 8 NSAIDs occurred in ibuprofen users and was 1.6/100000 . The other incidence in increasing order is as follows: oral diclofenac , naproxen , mefenamic acid , ketoprofen , piroxicam , fenbufen , sulindac 12
Postgraduate Medicine, 2018
- Compared to ibuprofen, risks of hepatoxicity are somewhat higher and better documented with acetaminophen, and reported to be higher amongst specific NSAIDs, such as oral diclofenac and sulindac13
Epidemiologic studies do not suggest that low dose ibuprofen is associated with an increased risk of renal adverse events
American Journal of Epidemiology, 2000
- Use of ibuprofen at 1200mg/day led to an odds ratio of 0.94 for renal AEs 9
- No major adverse events related to renal injury were identified during the study10
- After non-prescription doses of ibuprofen, renal injury were not amongst the reported adverse effects11
AE = adverse event CI = confidence interval GI = gastrointestinal NSAID = nonsteroidal anti-inflammatory drug OTC = over the counter.
Advil Multi Symptom Cold And Flu Medicine Cold Medicine For Adults With Ibuprofen Phenylephrine Hcl And Chlorpheniramine Maleate
$ as of January 8, 2022 5:59 am
- One bottle of 20 coated tablets of Advil Multi Symptom Cold and Flu Medicine, Cold Medicine for Adults with Ibuprofen, Phenylephrine HCL and Chlorpheniramine Maleate
- Powerful Ibuprofen 200mg, chlorpheniramine maleate 4mg and phenylephrine HCL 10 mg tablets for multi-symptom relief
- Uniquely formulated to fight common cold and flu symptoms, providing nasal congestion, nasal swelling, sneezing, sinus pressure, headache, fever, body aches and runny nose relief
- Cold medicine for adults available in easy-to-take coated tablet form
- For use by people 12 years of age and older
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Warning Disclaimer Use For Publication
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
How Does This Medication Work What Will It Do For Me
This product is a combination of 2 medications: ibuprofen and pseudoephedrine. Ibuprofen is a nonsteroidal anti-inflammatory drug that reduces pain, fever, and inflammation by reducing a substance in the body that leads to inflammation and pain. Pseudoephedrine is a that relieves the symptoms of nasal and sinus congestion by reducing swelling in nasal passages and sinuses.
This medication is used to relieve nasal congestion, sinus congestion, sinus pain, fever, headache, sore throat, and body aches and pains that are associated with the common cold, sinusitis, or the flu.
Your doctor or pharmacist may have suggested this medication for conditions other than the ones listed in this drug information article. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor or pharmacist.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor or pharmacist has not recommended it.
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Do Advil Gel Caps Contain Gluten
For instance, on the website for Advil gel caps, it will tell you they are contaminated with gluten because the gel contains a sugar alcohol, even though by the time they finish the process, the alcohol no longer contains a protein, the pharmacist says.
Can Advil Cold & Sinus Cause Any Cardiovascular Side Effects
Cardiovascular side effects in Advil Sinus users are rare, occurring in roughly 1-3% of patients. Symptoms include swelling of fingers and toes, high blood pressure and peripheral edema. Research shows that a chief ingredient of Advil Cold & Sinus, pseudoephedrine, may increase the severity of previous hypertension issues. Pseduophedrine may also be responsible for additional cardiovascular side effects such as coronary artery spasm and chest pain.
Find out whether you are predisposed to heart arrhythmias, as Advil Cold & Sinus is known to increase the likelihood of future incidents of arrhythmia in a small percentage of patients.
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Rite Aid Daytime Severe Sinus Congestion & Pain Relief
as of January 8, 2022 5:59 am
- FEVER & PAIN RELIEVER: 325mg of Acetaminophen in each caplet temporally relieves common cold symptoms like minor aches and pains, headache, sore throat, and fever. While the expectorant and nasal decongestant clear mucus and nasal congestion.
- MULTI-SYMPTOM RELIEF: Rite Aid Severe Sinus Congestion & Pain Relief relieves headache, nasal congestion, sinus congestion and sinus pressure, chest congestion and mucus. Compare the active ingredients to the national brand and get the same benefits.
- DAYTIME NON-DROWSY FORMULA: With Rite Aid cold medicine for adults, youll feel relief from symptoms associated with the common cold formulated without ingredients that may cause drowsiness So you can take on the day without feeling drowsy.
- FOR YOUR SEVERE SYMPTOMS: With Rite Aid Severe Cold & Flu sinus medicine for adults, youll get a pain reliever/fever reducer, cough suppressant to calm your cough, expectorant to power through mucus, and nasal decongestants for adults for congestion.
- TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the health and wellness of our communities and provide our customers with the best products, services, and advice.
Ask A Doctor Before Use If
- stomach bleeding warning applies to you
- you have problems or serious side effects from taking pain relievers or fever reducers
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, have trouble urinating due to an enlarged prostate gland, or had a stroke
- you are taking a diuretic
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Who Should Not Take This Medication
Do not take this medication if you:
- are allergic or sensitive to ibuprofen, pseudoephedrine, or any ingredients of the medication
- are allergic to other NSAIDs or ASA
- are about to have or have just had heart surgery
- are dehydrated due to vomiting, diarrhea, or not drinking enough fluids
- are taking another NSAID
- are pregnant or breast-feeding
- have taken a monoamine oxidase inhibitor within the last 14 days
- have thyroid disease
Why You Should Stop Wasting Your Money On Cold Medicine
To the sick, to the allergic, to the tissue-clutching, stuffy-nosed sufferer, there’s a certain aisle in the drugstore that offers unbridled hope, where shelves overflow with cold and sinus medicines advertising relief. It seems all a bleary-eyed person needs to do is pluck one from a cornucopia and breathe easy.
Now, science has a more definitive solution to our drugstore dilemma: keep on walking.
A study published in the Journal of Allergy and Clinical Immunology: In Practice in September examined phenylephrine, the decongestant that appears in many over-the-counter cold medicines found on store shelves, from Tylenol Sinus to Sudafed PE to Advil Sinus Congestion & Pain. Phenylephrine worked no better than a placebo at reducing nasal congestion in people suffering from seasonal allergies — even at doses four times higher than is typical in cold or sinus medicines.
“It’s a ripoff,” said Leslie Hendeles, a professor of pharmacy and pediatrics at the University of Florida who receives no funding from drug companies and wrote an accompanying editorial. “Right now, people with a stuffy nose deserve to get relief from an effective medicine.”
The study, funded by the pharmaceutical company Merck , is just the latest piece of evidence to cast doubt on the effectiveness of phenylephrine.
So why does phenylephrine persist?
So, advice one step better next time you feel the sniffles coming on: Save your money for soup.
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How Advil Cold & Sinus Works
Many people attribute the stuffiness associated with the cold or the flu to an increase in mucus which blocks their airways. While it is true that increased mucus is a symptom of the common cold, it is not always what causes you to feel so stuffed up. Instead, the true source of nasal and sinus congestion is often caused by inflammation of the tissues throughout the nose and face. When the body identifies a virus it considers a threat, it springs to defense in various ways, one of which is by causing the airways within the nose and sinuses to swell and become inflamed.
Advil Cold & Sinus is a combination of pseudoephedrine and ibuprofen . The two work together to reduce nasal and sinus congestion caused by inflammation and lessen the pain associated with the common cold or the flu.
How Should I Use This Medication
The usual recommended dose for adults and children older than 12 years is 1 or 2 caplets or liqui-gels every 4 to 6 hours as needed. Do not take more than 6 caplets or liqui-gels in 24 hours unless recommended by your doctor. Do not take for more than 3 days for a fever or for more than 5 days for cold symptoms.
For the children’s suspension, the dose depends on the child’s age and weight and is given every 6 hours as needed. Do not give more than 4 doses a day unless recommended by your doctor. Use an oral syringe or medication cup to measure each dose of the suspension, as it gives a more accurate measurement than household teaspoons. Shake the suspension well before measuring a dose.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as recommended by your doctor or pharmacist. If you are taking this medication regularly and you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Is Paracetamol Gluten Free
We can now confirm that all the ingredients used in Calpol Infant and SixPlus paracetamol suspensions do not contain gluten. Calpol Infant and SixPlus paracetamol suspensions do not contain gluten. Calpol Infant and SixPlus paracetamol suspensions do not contain gluten.
How Should I Take Advil Cold & Sinus
Use exactly as directed on the label, or as prescribed by your doctor. An overdose of ibuprofen can damage your stomach or intestines.
Take Advil Cold & Sinus with food or milk to lessen stomach upset.
If you need surgery, tell the surgeon ahead of time if you have taken this medicine within the past few days.
Store at room temperature away from moisture and heat.
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Who Should Not Take Advil Cold & Sinus Medication
If you are particularly sensitive to, or have a history of allergic reactions to the active ingredients in Advil Cold & Sinus consult first with your doctor before taking it. Those who have recently undergone heart surgery should call a doctor before taking the medication. Pregnant women or women who are breast-feeding should talk to their doctor before taking Advil Cold & Sinus.
Your Safety First
Those with certain medical conditions should avoid taking Advil to treat sinus infections, particularly those who suffer from liver disease, heart disease, severe high blood pressure, Raynauds Syndrome, Crohns disease, or angioedema syndrome. If you are a smoker, you may also be an increased risk of suffering from both mild and severe side effects.
Note: This article does not contain an exhaustive list of side effects, as every medication includes adverse symptoms that have not yet been reported. Be sure to contact your primary care physician if you experience any abnormal side effects, and report them to the Food and Drug Administration. Call 911 if you have severe side-effects.
Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
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Advil Cold & Sinus Side Effects
Get emergency medical help if you have signs of an allergic reactionor a severe skin reaction .
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.
Stop using Advil Cold & Sinus and call your doctor at once if you have:
confusion, severe drowsiness, ringing in your ears, severe dizziness, feeling like you might pass out
fast, pounding, or uneven heartbeat
easy bruising or bleeding
a skin rash, no matter how mild
signs of stomach bleedingbloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
liver problemsloss of appetite, stomach pain , tiredness, itching, dark urine, clay-colored stools, jaundice
kidney problemslittle or no urination, swelling in your feet or ankles, feeling tired or short of breath or
nerve problemsfever, headache, neck stiffness, chills, increased sensitivity to light, seizure .
Common side effects may include:
Stop Use And Ask A Doctor If
- you experience any of the following signs of stomach bleeding:
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms of heart problems or stroke:
- weakness in one part or side of body
- fever gets worse or lasts more than 3 days
- nasal congestion lasts for more than 7 days
- symptoms continue or get worse
- redness or swelling is present in the painful area
- you get nervous, dizzy, or sleepless
- any new symptoms appear
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