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When you have a cold or an allergy attack, your white blood cells gather in your nasal passages and sinuses. This causes nasal membranes to swell and increases mucus production. Pseudoephedrine constricts these blood vessels, which decreases drainage.

But those same constricted vessels might also increase your blood pressure and heart rate.

Pharmacist Kayla Ryan explains the mechanism of pseudoephedrine. Pseudoephedrine is chemically similar to adrenaline, so the body recognizes it as adrenaline, causing the blood pressure and heart rate to increase.

She refers to one of the last major studies of the effects of pseudoephedrine on blood pressure, which took place in 2005. This study found that pseudoephedrine increased systolic blood pressure by one point on average, while heart rate increased by an average of three beats per minute.

Ryan adds that the immediate-release products had a greater impact on heart rate and blood pressure than their 12 hour or 24 hour extended-release counterparts, which showed a smaller increase in blood pressure.

In 2005, the FDA passed the Combat Methamphetamine Act, which requires pharmacies to sell all medications containing pseudoephedrine behind the counter. At your local drugstore, youll find cards in the cold and flu aisle with information for these medications. You can take the card to the pharmacist, who is required to scan your drivers license before purchase.

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Although some allergy medicines affect your blood pressure or interact with your blood pressure medication, safe options for treating your allergy symptoms exist if you have high blood pressure.

Second-generation antihistamines that are not combined with decongestants are generally safe to use if you are not taking the blood pressure medicines listed in the drug interaction section above. Second-generation antihistamines include the following:

  • Allegra

If your symptoms include nasal congestion, the following options are generally safe to use as decongestants:

  • steroid nasal sprays, such as Flonase , Nasacort , and Rhinocort
  • antihistamine nasal sprays, such as Astelin and Patanase
  • saline nasal sprays or rinses, such as Ayr, Ocean, Simply Saline, or Neti Pot

Antihistamine eye drops, such as Pataday and Zaditor , are safe options for itchy watery eyes.

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